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Epistane - Simply



Epistane is a drug which often attracts a lot of confusion because the way it works means it can be classified as either a designer anabolic steroid, or a prohormone.

Strictly speaking, it’s a prohormone which meant that until the FDA clamped down, you could buy Epistane legally.

The drug is derived from dihydrotestosterone (DHT), a compound which has some similarities with epitiostanol , an anti-estrogen drug. Epistane has shown to lower the production of estrogen but it is not strictly speaking an aromatase inhibitor. However, because of these qualities, while you’re taking it you won’t have to combat any of the estrogenic effects that can be so problematic.

Although the popularity of Epistane only really started to rocket in 2006 when it was remarketed, the drug has been around since the mid-1960s when it was originally discovered by Japanese researchers.

Epistane was first developed in a bid to create a methylated version of another drug, mepitiostane, which could be used to treat breast cancer by reducing high levels of estrogen. The plan was for this drug to be available to take orally alongside Nolvadex.

epistane chemical structure

However, despite the medical background, when the drug was relaunched in 2006, it was as a dietary supplement, and it is in this field where demand is still primarily focused.

Can Epistane be taken on its own?

Although it’s entirely possible to take Epistane on its own to great effect, it’s recommended that creatine and a multi vitamin are used as on-cycle support.

If you opt for an Epistane cycle without any other performance enhancing drugs, you won’t see quite as extreme effects as using anabolic steroids. This doesn’t mean that an Epistane cycle alone isn’t effective or worthwhile, particularly for the purposes of cutting.

Stacking Info

Stacking isn’t for inexperienced users, so should only be used as part of an intermediate or advanced cycle where the individual has already had previous experience of taking similar drugs. For those who have completed prior cycles, Epistane does stack very well with lots of other compounds including both prohormones and steroids.

However, it is absolutely essential that other methylated compounds are not taken at the same time because the load onto the liver will become too much. Any other drugs included in an Epistane stack must therefore be non-methylated in order to avoid hepatotoxicity.

How it is administered

One of the benefits of Epistane is that it is administered orally, so there’s none of the inconvenience of having to inject, unlike many anabolic steroids.

Dosage info

Users normally start at a dosage of 30mg, but this can be gradually increased up to 60mg per day if needed in divided doses.

Epistane for sale can normally be found in 10mg capsules which makes it easy to adjust the dose as required. Beginners should find a dose of 30mg taken 7 hours apart is plenty to produce the desired effect while experienced users will probably need to take 50-60mg per day, again with the same spacing.

A beginner’s cycle shouldn’t last more than four weeks but experienced users can extend up to six weeks.

Half life info

The half life of Epistane is short, lasting just six hours. This can be useful for those who plan on competing as it won’t linger in the system for long periods of time.

Taking a dose an hour before a training session can be beneficial but it’s usually not recommended to take Epistane to close to bedtime because of the possibility of altered sleep patterns.

Positive effects

Epistane is preferred by many as the single best compound for cutting, making it ideal for use prior to competitions to get a dry, hard look.

However, as well as reducing body fat, Epistane has many other positive effects. These include increasing strength levels and muscle gain, and also promoting a general sense of well-being and good mood. Some individuals may also notice that their libido increases.

Epistane doesn’t deliver the biggest strength gains, nor is it the most potent prohormone but it’s a feel-good drug that can offer very significant benefits for cutting cycles as well as adding lean gains.

Potential side effects

As a prohormone, the side effects are generally not as difficult to tolerate as conventional anabolic steroids and Epistane is typically one of the easiest on the body. This doesn’t mean it is completely free of side effects, and some users may experience more problems than others.

Androgenic effects

Epistane has a similar drug profile to the anabolic steroid, Anavar, offering much greater anabolic effects than androgenic. This means that users are unlikely to suffer any of the typical androgenic side effects such as growth of excess body hair, acne and oily skin. It is possible that androgenic effects may be felt, but the possibility is very low compared to other compounds.

Estrogen effects

Epistane is not an anti-estrogen specifically but is sometimes taken at low doses to help combat gynecomastia. You therefore will not experience any estrogenic side-effects while taking this drug including gyno or bloating.


Epistane also doesn’t mix very well with stimulants and can cause fainting attacks and raised blood pressure if taken together. Stimulants should therefore be avoided or if not possible, an alternative to epistane found instead.

epi (epistane) bottled

Hair loss

As a compound which has limited androgenic effects, the possibility of suffering hair loss with Epistane is relatively low. In addition, the only men who could be affected are those with a family history of male pattern baldness and who carry the defective gene.

Liver toxicity

Epistane is a methylated compound which means there is some strain on the liver. This won’t normally cause any toxicity before 4-6 weeks, but because of the risk beyond this, cycles should be strictly kept to within these limits.

Alcohol should be avoided completely during an Epistane cycle because of the risk of overloading the liver.

Other effects

Although the effects of Epistane are often mild, some problems may be experienced, often towards the end of the cycle. Lethargy can be one of the main effects along with a dryness and pain in the joints. This can be largely offset with a supplement designed to protect the muscles and bones.


If you’re taking drugs for anxiety or depression, you may well find that the symptoms you experience worsen while you’re on cycle. Therefore, Epistane is not advised for anyone with a history of severe mental health problems.

Is it best suited to cutting, bulking or both?

Epistane is usually thought to be best utilized on a cutting cycle, and will provide an overall body fat loss of between 2-4%. Simultaneous gains of around 4-6lbs can be expected on a 40mg dose.

It can also be used for bulking, with gains lean and hard, rather than soft and puffy. Expect to add around 7-10lbs while also possibly reducing overall body fat from 1-3%. Similar effects will be seen while on a recomping cycle.

Although Epistane is undoubtedly best known for cutting, some users can pile on lean gains of up to 20lbs during a bulking cycle.

Is it safe for women to use?

Epistane is not recommended for use by women.

Type of PCT needed after the end of the cycle

PCT is required after taking Epistane and it should be commenced the day after taking the last dose. Nolvadex is the best drug to take, along with creatinine for the best results.

Because Epistane has an effect on the production of estrogen, there’s the possibility that when the cycle finishes, estrogenic side effects such as gyno, bloating and water retention can occur. Some experts suggest this can be particularly problematic when dropping from a high dose to complete cessation. Tailing off the Epistane more gradually may help reduce the incidence of estrogenic effects once the cycle finishes.

Typical cost

Epistane for sale can be found relatively cheaply with 60 tablets at a strength of 20mg each available for around $40.

Because Epistane is now a banned substance you won’t be able to purchase it from a drugstore or health food shop. You will be able to buy Epistane online particularly from overseas sources where it’s not illegal to buy or sell.

Sports that use it

Bodybuilding is the main sport which benefits from Epistane because of its ability to cut well and shred body fat. However, the drug could be used in any sport where lowering body fat while simultaneously maintaining and increasing muscle is desirable.

Some sources suggest that Epistane has even been used in college basketball because it’s mistakenly seen as “gentle” on the body compared to full anabolic steroids.

Legality of purchase and its usage in the US

Until the end of 2014 it was possible to buy prohormones legally but this was changed with the introduction of the Designer Anabolic Steroid Control Act of 2014.

This piece of legislation built upon the foundation laid down by the Controlled Substances Act, and allowed any drug or hormone which had a similar effect to anabolic steroids, or was chemically similar, to be treated as if they were actually a steroid. This means for all intents and purposes, the majority of prohormones including Epistane are now illegal.

The US takes a particularly tough stance on the use of steroids and other anabolic drugs, such as pro hormones. It is not only illegal to sell prohormones but it is also illegal to buy them. Elsewhere in the world, such as the UK and Europe, there are not such strict rules about the purchase of these drugs.

The change in law means that Epistane cannot be bought legally in the US and cannot be imported into the country, even if purchased legally overseas.